If you have played any of the Diablo games, you would know that the D2R Ladder Items are the life and soul of your equipment as they provide you with additional buff and effects on your already amazing weapons and equipment. However, if you want to get ahold of these runes, you have a certain grind set up for you. Particularly, if you have been trying to find High Runes in Diablo 2: Resurrected.
The Arcane Sanctuary
Arcane Sanctuary is another place where you can expect to obtain good high-level Runes. We all know this as the area where we find the which is the real tomb of Tal Rasha, out of all the seven we find throughout the desert.
All the ghosts in this place have a limited drop pool, so by killing them, you automatically have a higher chance of dropping runes.
However, if you want to improve your chances, make sure not to kill them off the path, and also check the end of the paths for additional chests.
These chests carry high-level loot within them, including these highly desired Runes, which can make the difference.
Another spot where you can try your luck is Tal Rasha’s tomb, where you find the last boss of Act 2, which is Duriel. He too can drop some pretty good ones, if you are lucky.
Secret Cow Level
Secret Cow Level is a great location for farming high runes, because of monster density the more monsters you kill the better chance you get of dropping high runes. You're going to be pumping up the drop rates of just regular white cows if you're playing single-player, unfortunately, there are a lot of good budget characters that can clear cows pretty efficiently. Because of mass monster density more monsters, you kill more chances you get dropping Diablo 2 Items for Sale , and then those drops could potentially be hybrids so make sure you farm lots of the Secret Cow Level.
Another location to farm for High Runes is Travincal. Comparatively, this location has a comparatively high drop rate, so the probability of you obtaining a valuable high rune would be high.
The farming technique for Travincal is similar to the Secret Cow Level. Keep killing the enemies that spawn till you get your hands on the rune.
Chaos is a bit trickier to estimate run times (or run amount for that matter), since some players cant just teleport in and will kill some mobs on the way. The run-amount will be far more important for chaos than the estimated time per Sur-value worth of runes. Figure out what percentage of mobs you kill in chaos, and multiply by your own run times to figure out your own estimates. Also, p8 with a full party of 8 will also be included here, since it is one of the only runs that people will be doing in groups. Dont expect to get every HR that drops in full games though, this is just how many will be dropping in total.
Ghosts here drop the same amount of runes as unique minion ghosts in arcane, but one Rune TC higher - the same chance to drop a rune, except now it can be Zod as well (only 2% higher value overall though, like I mentioned). Non-ghosts in Chaos Sanctuary actually drop out of the same TC as each other (venom lords, oblivion knights, and doom knights), including the minions of Seis and Infector, which drop far fewer HR's than the ghosts. In my testing, I found that the ratio of non-ghosts to ghosts was about 2.33 to 1. This means that only about 30% of the mobs in chaos have the juicy droprates for HR's.